1. Zhang Y, Lv FX, Jin L, Peng W, Song RS, Ma J, Cao CM , Xiao RP. MG53 Participates in Ischemic Postconditioning through the RISK Signaling Pathway, Cardiovascular Res. 2011, 91(1):108-15. 

2. Huang Y, Hong J, Zhen S, Ding Y, Guo S, Zhang H, Zhang X, Du Q, Liang Z. Elimination pathways of systemically delivered siRNA, Molecular Therapy. 2011, 19(2):381-5.

3. Luo J, Xiong Y, Han X, Lu Y. VEGF Non-angiogenic Functions in Adult Organ Homeostasis: Therapeutic Implications. J Mol Med. 2011, 89(7):635-45.

4. Brochet DX, Xie W, Yang D, Cheng H, Lederer WJ. Quarky Calcium Release in the Heart. Circ Res. 2011,108(2):210-8.

5. Sun Z, Zhang J, Zhang J, Chen C, Du Q, Chang L, Cao C, Zheng M, Garcia-Barrio MT, Chen YE, Xiao RP, Mao J, Zhu X. Rad GTPase induces cardiomyocyte apoptosis through the activation of p38 mitogen-activated protein kinase. Biochem Biophys Res Commun. 2011,409(1):52-7.

6. Luo Y, Zhang M, Zhang J, Zhang J, Chen C, Chen YE, Xiong JW, Zhu X. Rad Expression through Egr-1 in Vascular Smooth Muscle Cells, PLoS One.2011;6(4):e19408.

7. Zhang J, Chang L, Chen C, Zhang M, Luo Y, Hamblin M, Villacorta L, Xiong JW,Chen YE, Zhang J, Zhu X. Rad GTPase inhibits cardiac fibrosis through connective tissue growth factor. Cardiovasc Res. 2011,91(1):90-8.

8. Lin N, Badie N, Yu L, Abraham D, Cheng H, Bursac N, Rockman HA, Wolf MJ. A method to measure myocardial calcium handling in adult Drosophila. Circ Res. 2011, 108(11):1306-15. 

9. Zhou Q, Xiao J, Jiang D, Wang R, Vembaiyan K, Wang A, Smith CD, Xie C, Chen W, Tian X, Jones PP, Zhong X, Guo A,Zhang J, Chen H, Zhang L, Yang D, Li X, Chen J, Gillis AM, Duff HJ, Cheng H, Song L, Fill M, Back TG, and Chen SRW. Carvedilol and its new analogs suppress arrhythmogenic store overload-induced Ca2+ release, Nat Med. 2011, 17(8):1003-9.

10. Fang H, Chen M, Ding Y, Shang W, Xu J, Zhang X, Zhang W, Li K, Xiao Y, Gao F, Shang S, Li JC, Tian XL, Wang SQ, Zhou J, Weisleder N, Ma J, Ouyang K, Chen J, Wang X, Zheng M, Wang W, Zhang X, Cheng H. Imaging superoxide flash and metabolism-coupled mitochondrial permeability transition in living animals. Cell Res. 2011, 21(9):1295-304.

11. Ma Q, Fang H, Shang W, Liu L, Xu Z, Ye T, Wang X, Zheng M, Chen Q, Cheng H. Superoxide flashes: early mitochondrial signals for oxidative stress-induced apoptosis. J Biol Chem. 2011, 286(31):27573-81. 

12. Zhang B, Sun L, Yang Y, Huang H, Zhu F, Wang L, Zhang X, Guo S, Zuo P, Zhang X, Ding J., Wang L, Zhou Z. Action potential bursts enhance transmitter release at a giant central synapse. Journal of Physiology. 2011, 589(9):2213–2227.

13. Wang SR, Yao W, Huang HP, Zhang B, Zuo PL, Sun L, Dou HQ, Li Q, Kang XJ, Xu HD, Hu MQ, Jin M, Zhang L, Mu Y, Peng JY, Zhang CX, Ding JP, Li BM, Zhou Z. Role of vesicle pools in action potential pattern-dependent dopamine overflow in rat striatum in vivo. Journal of Neurochemistry. 2011(119):342–353.

14. Xiong W, Liu T, Wang YS, Chen XW, Sun L, Guo N, Zheng H, Zheng LH, Ruat M, Han WP, Zhang CX, and Zhou Z. An Inhibitory Effect of Extracellular Ca2+ on Ca2+ Dependent Exocytosis. PLoS One.2011, 6:e24573.

15. Liu T, Sun L, Xiong Y, Shang S, Guo N, Teng S, Wang Y, Liu B, Wang C, Wang L, Zheng L. Calcium triggers quantal release simultaneously from two types of vesicles in a single astrocyte. Journal of Neuroscience.2011, 31:10593–10601.

16. Liu T, Shang S, Liu B, Wang C, Wang Y, Xiong W, Zheng L, Zhang X, and Zhou Z. Two distinct vesicle pools for depolarization-induced exocytosis in somata of dorsal root ganglion neurons. Journal of Physiology. 2011, 589:3507–3515.

17. Talan MI, Ahmet I, Xiao RP, Lakatta EG. b(2) AR Agonists in Treatment of Chronic Heart Failure: Long Path to Translation. J Mol Cell Cardiol. 2011,51(4):529-33.

18. Chakir K, Zhu W, Tsang S, Woo AY, Yang D, Wang X, Zeng X, Rhee MH, Mende U, Koitabashi N, Takimoto E, Blumer KJ, Lakatta EG, Kass DA, Xiao RP. RGS2 is a primary terminator of β2-adrenergic receptor-mediated G(i) signaling. J Mol Cell Cardiol. 2011, 50(6):1000-7.

19. Zhou J, Neff CP, Liu X, Zhang J, Li H, Smith DD, Swiderski P, Aboellail T, Huang Y, Du Q, Liang Z, Peng L, Akkina R, Rossi JJ. Systemic Administration of Combinatorial dsiRNAs via Nanoparticles Efficiently Suppresses HIV-1 Infection in Humanized Mice. Mol Ther. 2011,19(2):2228-38.

20. Lin D, Huang Y, Jiang Q, Zhang W, Yue X, Guo S, Xiao P, Du Q, Xing J, Deng L, Liang Z, Dong A. Structural contributions of blocked or grafted poly(2-dimethylaminoethyl methacrylate on PEGylated polycaprolactone nanoparticles in siRNA delivery. Biomaterials. 2011,32(33):8730-42.

21. Wei Z, Zhao D, Li X, Wu M, Wang W, Huang H, Wang X, Du Q, Liang Z, Li Z. A laminar flow electroporation system for efficient DNA and siRNA delivery. Anal Chem. 2011, 83(15): 5881-7.

22. Guo S, Huang Y, Zhang W, Wang W, Wei T, Lin D, Xing J, Deng L, Du Q, Liang Z, Liang XJ, Dong A. Ternary complexes of amphiphilic polycaprolactone-graft-poly (N,N-dimethylaminoethyl methacrylate), DNA and polyglutamic acid-graft-poly(ethylene glycol) for gene delivery. Biomaterials. 2011,32(18):4283-92.

23. Lu Y, Zhang J, Xiong Y, Zhu N, Fan C, Wang S, Liu S, Liang Z, Shen Y, Wang Q, Chen M. Small interfering RNAs screened from random siRNA library direct neuronal differentiation.Biotechnol Lett. 2011,33(9):1737-44.

24. Fan C, Xiong Y, Zhu N, Lu Y, Zhang J, Wang S, Liang Z, Shen Y, Chen M. Random small interfering RNA library screen identifies siRNAs that induce human erythroleukemia cell differentiation. Leukemia & Lymphoma.2011,52(3):502-14.

25. Lu Y, Xiong Y, Huo Y, Han J, Yang X, Zhang R, Zhu DS, Klein-Hessling S, Li J, Zhang X, Han X, Li Y, Shen B, He Y, Shibuya M, Feng GS, Luo J. Gab1 regulates postnatal ischemic and VEGF-induced angiogenesis through activation of the PKA-eNOS pathway. Proc Natl Acad Sci U S A. 2011,108(7):2957-62. 

26. Guo S, Huang Y, Wei T, Zhang W, Wang W, Lin D, Zhang X, Kumar A, Du Q, Xing J, Deng L, Liang Z, Wang PC, Dong A, Liang XJ. Amphiphilic and biodegradable methoxy polyethylene glycol-block-(polycaprolactone-graft-poly(2-(dimethylamino)ethyl methacrylate)) as an effective gene carrier. Biomaterials.2011,32(3):879-89.

27. Yang Y, Jiang B, Huo Y, Primo L, Dahl JS, Benjamin TL, Luo J. Shp2 suppresses PyMT-induced transformation in mouse fibroblasts by inhibiting Stat3 activity. Virology. 2011, 409(2):204-10.

28. Zhang X,Zhang R,Raab S,Zheng W,Wang J,Liu N,Zhu T,Xue L,Song Z,Mao J,Li K,Zhang H,Zhang H,Zhang Y,Han C,Ding Y,Wang H,Hou N,Liu Y,Shang S,Li C,Sebokova E,Cheng H,Huang P. Rhesus macaques develop metabolic syndrome with reversible vascular dysfunction responsive to pioglitazon. Circulation.2011,124(1):77-86.

29. Han P, Cai W, Wang Y, Chi Keung Lam, Demetrios A. Arvanitis, Vivek P. Singh, Chen S, Zhang H, Zhang R, Cheng H, Evangelia G. Kranias1. Catecholaminergic Induced Arrhythmias in Failing Cardiomyocytes Associated with Human HRCS96A Variant Overexpression. American Journal of Physiology- Heart and Circulatory Physiology, 2011, 301 (4) :H1588-H1595.

30. Huang H, Wei Z, Huang Y, Zhao D, Zheng L, Cai T, Wu M, Wang W, Ding X, Zhou Z, Du Q, Li Z, Liang Z . An efficient and high-throughput electroporation microchip applicable for siRNA delivery. Lab Chip. 2011,11:163-172.

31. Malboubi M, Gu Y, and Jiang K. Characterization of surface properties of glass micropipettes using SEM stereoscopic technique. Microelectronic Engineering, 2011, 88(8):2666-2670.

32. Huang Z, Zhang W, Gong G, Fang H, Zheng M, Wang X, Xu J, Dirksen RT, Sheu SS, Cheng H, Wang W. Response to "A critical evaluation of cpYFP as a probe for superoxide". Free Radical Biology & Medicine. 2011,51(10):1937-40.

33. Jin Y, Wu J, Song X, Song Q, Cully BL, Messmer-Blust A, Xu M, Foo SY, Rosenzweig A and Li J. RTEF-1, an Upstream Gene of Hypoxia-inducible Factor-1α,Accelerates Recovery from Ischemia. J Biol Chem.2011,286(25):22699-22705.

34. Jiang F, Dong Y, Wu C, Yang X, Zhao L, Guo J, Li Y, Dong J, Zheng GY, Cao H, Jin L, Ren Y, Cheng W, Li W, Tian XL, Li X. Fine mapping of chromosome 3q22.3 identifies two haplotype blocks in ESYT3 associated with coronary artery disease in female Han Chinese. Atherosclerosis.2011,218(2):397-403.

35. Liang K, Du W, Zhu W, Liu S, Cui Y, Sun H, Luo B, Xue Y, Yang L, Chen L, Li F. Contribution of different mechanisms to pancreatic beta-cell hyper-secretion in NOD mice during pre-diabetes. J Biol Chem. 2011;286(45):39537-45.

36. Wu J, Wang S, Gu Y, Zhang S, Publicover SJ, Franklin-Tong VE. Self-incompatibility in papaver rhoeas activates nonspecific cation conductance permeable to Ca2+ and K+. Plant Physiol. 2011, 155(2):963-73.

37. Li CY, Zhou W, Zhang P, Catherine J, Wei L, George R. Meta-analysis and genome-wide interpretation of genetic susceptibility to drug addiction. BMC Genomics. 2011, 12:508.

38. Xie C, Mao X, Huang J, Ding Y, Wu J, Dong S, Kong L, Gao G, Li CY, Wei L. KOBAS 2.0: a web server for annotation and identification of enriched pathways and diseases. Nucleic Acid Research, 2011,39 (suppl 2): W316-W322.

39. Wei C, Wang X, Zheng M, Cheng H. Calcium Gradients Underlying Cell Migration. Current Opinion In Cell Biology.2011,24:1-8.


1. Cao CM, Zhang Y, Weisleder N, Ferrante C, Wang X, Lv F, Zhang Y, Song R, Hwang M, Jin L, Guo J, Peng W, Li G, Nishi M, Takeshima H, Ma J, Xiao RP. MG53 Constitutes a Primary Determinant of Cardiac Ischemic Preconditioning. Circulation.  2010,121:2565-74.

2. Xie W, Brochet DX, Wei S, Wang X, Cheng H. Deciphering Ryanodine Receptor Array Operation in Cardiac Myocytes.Journal of General Physiology. 2010,136(2):129-33.

3. Peng W, Zhang Y, Zheng M, Cheng H, Zhu W, Cao CM, Xiao RP. Cardioprotection by CaMKII-B Is Mediated by Phosphorylation of Heat Shock Factor 1 and Subsequent Expression of Inducible Heat Shock Protein 70. Circ Res. 2010,106(1):102-10.

4. Li Q, Lan XM, Li G, Zheng M, Chen KH, Cao CM, Xiao RP. Receptor Interacting Protein 3 Suppresses Vascular Smooth Muscle Cell Growth by Inhibition of the Phosphoinositide 3-Kinase-Akt Axis. J Biol Chem. 2010,285(13):9535-44.

5. Zhang Y, Cao CM, Xiao RP. Kinase Activity-Independent Anchoring Function of Protein Kinase C. Focus on protein kinase C regulates the subcellular localization of Shc in H2O2-treated cardiomyocytes. Am J Physiol Cell Physiol. 2010, 299(4):C733-5.

6. Zheng M, Xiao RP. Role of Mitofusin 2 in Cardiovascular Oxidative Stress. J. Mol. Med. 2010, 88: 987-91. 

7. Zheng M, Cheng H, Banerjee I, Chen J. ALP/Enigma PDZ–LIM Domain Proteins in the Heart. J Mol Cell Biol. 2010, 2(2): 96–102.

8. Wang X, Xie W, Zhang Y, Lin P, Han L, Han P, Wan, Y, Chen Z, Ji G, Zheng M, Weisleder N, Xiao RP, Takeshima H, Ma J, Cheng H. Cardioprotection of ischemia/reperfusion injury by cholesterol-dependent MG53-mediated membrane repair. Circ Res. 2010,107:76-83. 

9. Li CY, Zhang Y, Wang Z, Zhang Y, Cao CM, Zhang PW, Lu SJ, Li XM, Yu Q, Zheng X, Du Q, Uhl GR, Liu QR, Wei L. A Human-Specific De Novo Protein-Coding Gene Associated with Human Brain Functions. PLoS Comput Biol. 2010,6(3):e1000734.

10. Li B, Chen F, Ye J, Chen X, Yan J, Li Y, Xiong Y, Zhou Z, Xia J, Hu Z. The Modulation of Orexin A on HCN Currents of Pyramidal Neurons in Mouse Prelimbic Cortex. Cerebral Cortex. 2010, 20(7):1756-67.

11. Zhang Y, Su P, Liang P, Liu T, Liu X, Liu XY, Zhang B, Han T, Zhu YB, Yin DM, Li J, Zhou Z, Wang KW, Wang Y.The DREAM Protein Negatively Regulates the NMDA Receptor through Interaction with the NR1 Subunit .J. Neurosci. 2010,30(22):7575-86.

12. Wang G, Zhu X, Xie W, Han P, Li K, Sun Z, Wang Y, Chen C, Song R, Cao C, Zhang J, Wu C, Liu J, Cheng H. Rad As a Novel Regulator of Excitation-Contraction Coupling and beta-Adrenergic Signaling in Heart. Circ. Res. 2010,106(2):317-27.

13. Xiong J, Du Q, Liang Z. Tumor-suppressive microRNA-22 inhibits the transcription of E-box-containing c-Myc target genes by silencing c-Myc binding protein. Oncogene. 2010, 29(35):4980-8. 

14. Wei S, Guo A, Chen B, Kutschke W, Xie YP, Zimmerman K, Weiss RM, Anderson ME, Cheng H, Song LS. T-tubule remodeling during transition from hypertrophy to heart failure. Circ Res. 2010,7(4):520-31.

15. Xiong J, Yu D, Wei N, Cai T, Huang Y, Zheng X, Du Q, Lin D and Liang Z . An estrogen receptor alpha suppressor, microRNA-22, is downregulated in estrogen receptor alpha-positive human breast cancer cell lines and clinical samples. FEBS J. 2010, 277(7):1684-94.

16. Hong J, Huang Y, Li J, Yi F, Zheng J, Huang H, Wei N, Shan Y, An M, Zhang H, Ji J, Zhang P, Xi Z, Du Q and Liang Z. Comprehensive analysis of sequence-specific stability of siRNA. FASEB J. 2010,24(12):4844-55.

17. Li J, Romestaing C, Han X, Li Y, Hao X, Wu Y, Sun C, Liu X, Jefferson LS, Xiong J, Lanoue KF, Chang Z, Lynch CJ, Wang H, Shi Y. Cardiolipin Remodeling by ALCAT1 Links Oxidative Stress and Mitochondrial Dysfunction to Obesity. Cell Metabolism. 2010, 12 (2):154-65. 

18. Zhang L, Zhou F, Han W, Shen B, Luo J, Shibuya M, He Y. VEGFR-3 ligand-binding and kinase activity are required for lymphangiogenesis but not for angiogenesis. Cell Res. 2010, 20(12):1319-31.

19. Guo S, Huang Y, Jiang Q, Sun Y, Deng L, Liang Z, Du Q, Xing J, Zhao Y, Wang P, Dong A and Liang X. Enhanced Gene Delivery and siRNA Silencing by Gold Nanoparticles Coated with Charge-Reversal Polyelectrolyte. ACS Nano. 2010, 4(9):5505-11.

20. Li J, Liang Z. The Consideration of Synthetic Short Interfering RNA for Therapeutic Use. Basic Clin Pharmacol Toxicol. 2010,106(1):22-9. 

21. Xiong X, Lu Y, Zhang L, Wang B, Zhao Y, Wang XJ, Huo X, Shen Y, Liang Z, Chen M. Discovery of Novel Cell Proliferation-Enhancing Gene by Random siRNA Library Based Combinatorial Screening. Combinatorial Chemistry & High Throughput Screening. 2010,13(9):798-806.

22. Chen LY, Zhao WH, Tian W, Guo J, Jiang F, Jin LJ, Sun YX, Chen KM, An LL, Li GD, Li Q, Li Y, Wu C, Zhao L, Wang WJ, Zheng GY, Li B, Li XQ, Hu J, Tian XL. STK39 is an independent risk factor for male hypertension in Han Chinese. International Journal of Cardiology. 2010(on line).

23. Zeng Y, Cheng L, Chen H, Cao H, Hauser ER, Liu Y, Xiao Z, Tan Q, Tian XL, Vaupel JW. Effects of FOXO Genotypes on Longevity: A Biodemographic Analysis. J Gerontol A Biol Sci Med Sci. 2010, 65(12):1285-99.

24. Chen M, Wang Y, Qu A. PGC-1a accelerates cytosolic Ca2+ clearance without disturbing Ca2+ homeostasis in cardiac myocytes. Biochem Biophys Res Commun. 2010,396(4):894-900. 

25. Lu L, Xia L, Ye X, Cheng H. Simulation of the effect of rogue ryanodine receptors on a calcium wave in ventricular myocytes with heart failure. Phys. Biol. 2010,7(2):6005-10. 

26. Yu L, Lee T, Lin N, Wolf MJ. Affecting Rhomboid-3 Function Causes a Dilated Heart in Adult Drosophila. PLoS Genetics, 2010(6):e1000969.

27. Wei C, Wang X, Chen M, Ouyang K, Zheng M, Cheng H. Flickering calcium microdomains signal turning of migrating cells. Can J Physiol Pharm. 2010,88(2):105-10.


1. Wei C, Wang X, Chen M, Ouyang K, Song LS, Cheng H. Calcium flickers steer cell migration. Nature. 2009, 457(7231): 901-5.

2. Zheng M, Cheng H, Li X, Zhang J, Cui L, Ouyang K, Han L, Zhao T, Gu Y, Dalton ND, Bang ML, Peterson KL, Chen J. Cardiac-specific ablation of Cypher leads to a severe form of dilated cardiomyopathy with premature death. Hum Mol Genet. 2009, 18(4):701-13.

3. Xiong Y, Huo Y, Chen C, Zeng H, Lu X, Wei C, Ruan C, Zhang X, Hu Z, Shibuya M, Luo J. Vascular endothelial growth factor (VEGF) receptor-2 tyrosine 1175 signaling controls VEGF-induced von Willebrand factor release from endothelial cells via phospholipase C-gamma 1- and protein kinase A-dependent pathways. J Biol Chem. 2009, 284(35):23217- 24.

4. Zhou P, Zhao YT, Guo YB, Xu SM, Bai SH, Lakatta EG, Cheng H, Hao XM, Wang SQ. Beta-adrenergic signaling accelerates and synchronizes cardiac ryanodine receptor response to a single L-type Ca2+ channel. Proc Natl Acad Sci U S A. 2009, 106(42):18028-33.

5. Zheng H, Fan J, Xiong W, Zhang C, Wang XB, Liu T, Liu HJ, Sun L, Wang YS, Zheng LH, Wang BR, Zhang CX, Zhou Z. Action Potential Modulates Ca2+-Dependent and Ca2+-Independent Secretion in a Sensory Neuron. Biophys J. 2009, 96(6): 2449-56.

6. Misler S, Zhou Z, Dickey AS, Silva AM, Pressel DM, Barnett DW. Biphasic insulin secretion from beta-cells of canine islets of Langerhans: tuning two modes of exocytosis to two modes of glucose-induced electrical activity. Channels. 2009, 3(3): 181-93.

7. Fan J, Zhang B, Shu HF, Zhang XY, Wang X, Kuang F, Liu L, Peng ZW, Wu R, Zhou Z, Wang BR. Interleukin-6 increases intracellular Ca2+ concentration and induces catecholamine secretion in rat carotid body glomus cells. J Neurosci Res. 2009, 87(12):2757-62.

8. Peng W, Zhang Y, Zhu W, Cao CM, Xiao RP. AMPK and TNF-alpha at the crossroad of cell survival and death in ischaemic heart. Cardiovasc Res. 2009, 84(1):1-3.

9. Huang H, Qiao R, Zhao D, Zhang T, Li Y, Yi F, Lai F, Hong J, Ding X, Yang Z, Zhang L, Du Q, Liang Z. Profiling of mismatch discrimination in RNAi enabled rational design of allele-specific siRNAs. Nucleic Acids Res. 2009, 37(22):7560-9.

10. Xue Y, Petrovic N, Cao R, Larsson O, Lim S, Chen S, Feldmann HM, Liang Z, Zhu Z, Nedergaard J, Cannon B, Cao Y. Hypoxia-independent angiogenesis in adipose tissues during cold acclimation. Cell Metab. 2009, 9(1):99-109.

11. Li Y, Wang WJ, Cao H, Lu J, Wu C, Hu FY, Guo J, Zhao L, Yang F, Zhang YX, Li W, Zheng GY, Cui H, Chen X, Zhu Z, He H, Dong B, Mo X, Zeng Y, Tian XL. Genetic association of FOXO1A and FOXO3A with longevity trait in Han Chinese populations. Hum Mol Genet. 2009, 18(24):4897-904.

12. An X, Jin Y, Guo H, Foo SY, Cully BL, Wu J, Zeng H, Rosenzweig A, Li J. Response gene to complement 32, a novel hypoxia-regulated angiogenic inhibitor. Circulation. 2009, 120(7): 617-27.

13. Jin Y, An X, Ye Z, Cully B, Wu J, Li J. RGS5, a hypoxia-inducible apoptotic stimulator in endothelial cells. J Biol Chem 2009, 284(35): 23436–43.

14. Yuan Q, Han P, Dong M, Ren X, Zhou X, Chen S, Jones WK, Chu G, Wang HS, Kranias EG. Partial downregulation of junctin enhances cardiac calcium cycling without eliciting ventricular arrhythmias in mice. Am J Physiol Heart Circ Physiol. 2009, 296(5):H1484-90.

15. Xiong JW, Zhu L, Jiao X, Liu SS. Evidence for pH surface component of proton motive force in ATP synthesis of mitochondria. Biochim Biophys Acta. 2009, 1800(3):213-22. 

16. Liu XX, Rocchi P, Qu FQ, Zheng SQ, Liang ZC, Gleave M, Iovanna J, Peng L. PAMAM dendrimers mediate siRNA delivery to target Hsp27 and produce potent antiproliferative effects on prostate cancer cells. ChemMedChem. 2009, 4(8):1302-10.

17. Xie CQ, Huang H, Wei S, Song LS, Zhang J, Ritchie RP, Chen L, Zhang M, and Chen YE. A Comparison of Murine Smooth Muscle Cells Generated from Embryonic versus Induced Pluripotent Stem Cells. Stem Cells and Development, 2009,18(5):741-748.


1. Deng J, Wang G, Huang Q, Yan Y, Li K, Tan W, Jin C, Wang Y, Liu J. Oxidative stress induced leaky sarcoplasmic reticulum underlying acute heart failure in severe burn trauma. Free Radic Biol and Med. 2008, 44 (3):375-85.

2. Yan Y, Liu J, Wei C, Li K, Xie W, Wang Y, Cheng H. Bidirectional regulation of Ca2+ sparks by mitochondria-derived reactive oxygen species in cardiac myocytes. Cardiovasc Res. 2008, 77(2):432-41.

3. Hong J, Wei N, Chalk A, Wang J, Song Y, Yi F, Qiao RP, Sonnhammer EL, Wahlestedt C, Liang Z, Du Q. Focusing on RISC assembly in mammalian cells. Biochem Biophys Res Commun. 2008, 368(3): 703-8.

4. Dahlgren C, Zhang HY, Du Q, Grahn M, Norstedt G, Wahlestedt C, Liang Z. Analysis of siRNA specificity on targets with double-nucleotide mismatches. Nucleic Acids Res. 2008, 36(9):e53. 

5. Chen XW, Mu Y, Huang HP, Guo N, Zhang B, Fan SY, Xiong JX, Wang SR, Xiong W, Huang W, Liu T, Zheng LH, Zhang CX, Li LH, Yu ZP, Hu ZA, Zhou Z. Hypocretin-1 potentiates NMDA receptor-mediated somatodendritic secretion from locus coeruleus neurons. J Neurosci. 2008, 28(12):3202-8.

6. Chen XW, Huang W, Yan JA, Fan HX, Guo N, Lü J, Xiu Y, Gu JL, Zhang CX, Ruan HZ, Hu ZA, Yu ZP, Zhou Z.Reinvestigation of the effect of orexin A on catecholamine release from adrenal chromaffin cells. Neurosci Lett. 2008, 436(2):181-4.

7. Chen XW, Feng YQ, Hao CJ, Guo XL, He X, Zhou ZY, Guo N, Huang HP, Xiong W, Zheng H, Zuo PL, Zhang CX, Li W, Zhou Z. DTNBP1, a schizophrenia susceptiblity gene, affects kinetics of transmitter release. J Cell Biol. 2008, 181(5): 791-801.

8. Wang W, Fang H, Groom L, Cheng A, Zhang W, Liu J, Wang X, Li K, Han P, Zheng M, Yin J, Wang W, Mattson MP, Kao JP, Lakatta EG, Sheu SS, Ouyang K, Chen J, Dirksen RT, Cheng H. Superoxide flashes in single mitochondria. Cell. 2008, 134(2):279-90. 

9. Luo D, Yang D, Lan X, Li K, Li X, Chen J, Zhang Y, Xiao RP, Han Q, Cheng H. Nuclear Ca2+ sparks and waves mediated by inositol 1,4,5-trisphosphate receptors in neonatal rat cardiomyocytes. Cell Calcium. 2008, 43(2):165-74.

10. Cheng H, Lederer WJ. Calcium Sparks. Physiol Rev. 2008, 88(4):1491-545.

11. Yang Z, Stratton C, Francis PJ, Kleinman ME, Tan PL, Gibbs D, Tong Z, Chen H, Constantine R, Yang X, Chen Y, Zeng J, Davey L, Ma X, Hau VS, Wang C, Harmon J, Buehler J, Pearson E, Patel S, Kaminoh Y, Watkins S, Luo L, Zabriskie NA, Bernstein PS, Cho W, Schwager A, Hinton DR, Klein ML, Hamon SC, Simmons E, Yu B, Campochiaro B, Sunness JS, Campochiaro P, Jorde L, Parmigiani G, Zack DJ, Katsanis N, Ambati J, Zhang K. Toll-like receptor 3 and geographic atrophy in age-related macular degeneration. N Engl J Med. 2008,235 (14):1456-63.


1. Huang HP, Wang SR, Yao W, Zhang C, Zhou Y, Chen XW, Zhang B, Xiong W, Wang LY, Zheng LH, Landry M, Hokfelt T, Xu ZQ, Zhou Z. Long latency of evoked quantal transmitter release from somata of locus coeruleus neurons in rat pontine slices. Proc Natl Acad Sci U S A. 2007, 104(4):1401-6.

2. Yang D, Zhu WZ, Xiao B, Brochet DX, Chen SR, Lakatta EG, Xiao RP, Cheng H. Ca2+/Calmodulin kinase II -dependent phosphorylation of ryanodine receptors suppresses Ca2+ sparks and Ca2+ waves in cardiac myocytes. Circ Res. 2007, 100(3):399-407.

3. Yu X, Chen XW, Zhou P, Yao L, Liu T, Zhang B, Li Y, Zheng H, Zheng LH, Zhang CX, Bruce I, Ge JB, Wang SQ, Hu ZA, Yu HG, Zhou Z. Calcium influx through If channels in rat ventricular myocytes. Am J Physiol Cell Physiol. 2007, 292 (3):C1147-55.

4. Zhao G, Zhao Y, Pan B, Liu J, Huang X, Zhang X, Cao C, Hou N, Wu C, Zhao KS, Cheng H. Hypersensitivity of BKCa to Ca2+ sparks underlies hyporeactivity of arterial smooth muscle in shock. Circ Res. 2007, 101(5):493-502.

5. Chen M, Du Q, Zhang HY, Wang X, Liang Z. High-throughput screening using siRNA (RNAi) libraries. Expert Rev Mol Diagn. 2007, 7(3):281-91.

6. Li ZS, Qiao RP, Du Q, Yang ZJ, Zhang LR, Zhang PZ, Liang ZC, Zhang LH. Studies on aminoisonucleoside modified siRNAs: stability and silencing activity. Bioconjug Chem. 2007, 18(4):1017-24.

7. Shen T, Zheng M, Cao C, Chen C, Tang J, Zhang W, Cheng H, Chen KH, Xiao RP. Mitofusin-2 is a major determinant of oxidative stress-mediated heart muscle cell apoptosis. J Biol Chem. 2007, 282(32):23354 -61.

8. Zhu W, Woo AY, Yang D, Cheng H, Crow MT, Xiao RP. Activation of CaMKII-delta C is a common intermediate of diverse death stimuli-induced heart muscle cell apoptosis. J Biol Chem. 2007, 282(14): 10833-9.

9. Zhu X, Lin Y, Bacanamwo M, Chang L, Chai R, Massud I, Zhang J, Garcia-Barrio MT, Thompson WE, Chen YE. Interleukin-1 induced Id2 gene expression is mediated by Egr-1 in vascular smooth muscle cells. Cardiovasc Res. 2007, 76(1): 141-8.

10. Zhang W, Zhang Y, Zheng H, Zhang C, Xiong W, Olyarchuk JG, Walker M, Xu W, Zhao M, Zhao S, Zhou Z, Wei L. SynDB: A Synapse protein DataBase based on synapse Ontology. Nucleic Acids Res. 2007, 35: D737- 41.

11. Tocchetti C, Wang W, Froehlich J, Huke S, Aon M, Wilson G, Benedetto G, Rourke B, Gao WD, Wink D, Toscano J, Zaccolo M, Bers D, Valdivia H, Cheng H, Kass D, Paolocci N. Nitroxyl improves cellular heart function by directly enhancing cardiac sarcoplasmic reticulum Ca2+ cycling. Circ Res. 2007, 100(1): 96-104.

12. Tan W, Fu CQ , Fu C, Xie W, Cheng H. An anomalous subdiffusion model for calcium spark in cardiac myocytes. Applied Physics Letters. 2007, 91(18): 693-5.

13. Xiao B, Tian X, Xie W, Jones PP, Cai S, Wang X, Jiang D, Zhang L, Cheng K, Walsh MP, Cheng H, Chen SR. Functional consequence of protein kinase A-dependent phosphorylation of the cardiac ryanodine receptor: sensitization of store overload-induced Ca2+ release. J Biol Chem. 2007, 282(41):30256-64.

14. Weisleder N, Ferrante C, Hirata Y, Collet C, Chu Y, Cheng H, Takeshima H, Ma J. Systemic ablation of RyR3 alters Ca2+ spark signaling in adult skeletal muscle. Cell Calcium. 2007, 42(6):548-55.

15. Shu HF, Wang BR, Wang SR, Yao W, Huang HP, Zhou Z, Wang X, Fan J, Wang T, Ju G.IL-1beta inhibits IK and increases [Ca2+]i in the carotid body glomus cells and increases carotid sinus nerve firings in the rat. Eur J Neurosci. 2007, 25(12): 3638 -47.

16. Chang L, Zhang J, Tseng YH, Xie CQ, Ilany J, Brüning JC, Sun Z, Zhu X, Cui T, Youker KA, Yang Q, Day SM, Kahn CR, Chen YE. Rad GTPase deficiency leads to cardiac hypertrophy. Circulation. 2007, 116(25): 2976-83.


1. Song LS, Sobie EA, McCulle S, Lederer WJ, Balke CW, Cheng H. Orphaned ryanodine receptors in the failing heart. Proc Natl Acad Sci U S A. 2006, 103(11): 4305-10.

2. Wu G, Luo J, Rana JS, Laham R, Sellke FW, Li J. Involvement of COX-2 in VEGF-induced angiogenesis via P38 and JNK pathways in vascular endothelial cells. Cardiovasc Res. 2006, 69(2): 512-9.

3. Wang LC, Xiong W, Zheng J, Zhou Y, Zheng H, Zhang C, Zheng LH, Zhu XL, Xiong ZQ, Wang LY, Cheng HP, Zhou Z. The timing of endocytosis after activation of a G-protein-coupled receptor in a sensory neuron. Biophys J. 2006, 90(10):3590-8.

4. Yao LJ, Wang G, Ou-Yang KF, Wei CL, Wang XH, Wang SR, Yao W, Huang HP, Luo JH, Wu CH, Liu J, Zhou Z, Cheng HP. Ca2+ sparks and Ca2+ glows in superior cervical ganglion neurons. Acta Pharmacol Sin. 2006, 27 (7): 848-52.

5. Chen XK, Xiong YF, Zhou Z. Kiss-and-Run exocytosis in astrocytes. Neuroscientist. 2006, 12(5): 375-8.

6. Cao CM, Yan WY, Liu J, Kam, KW, Zhan SZ, Sham, JS, Wong TM. Attenuation of mitochondrial, but not cytosolic, Ca2+ overload reduces myocardial injury induced by ischemia and reperfusion. Acta Pharmacol Sin. 2006, 7 (7): 911-8.

7. Yan Y, Wei CL, Zhang WR, Cheng HP, Liu J. Cross-talk between calcium and reactive oxygen species signaling. Acta Pharmacol Sin. 2006, 27(7):821-6.

8. Cheng HP, Wei S, Wei LP, Verkhratsky A. Calcium signaling in physiology and pathophysiology. Acta Pharmacol Sin. 2006, 27(7):767-72.

9. Feng Z, Wei C, Chen X, Wang J, Cheng H, Zhang X, Hong Q, Shi S, Fu B, Wei R. Essential role of Ca2+ release channels in angiotensin II-induced Ca2+ oscillations and mesangial cell contraction. Kidney Int. 2006, 70(1):130-8. 

10. Gao Y, Sun L, Dong J, Xu X, Shu Y, Chen M, Yin L, Liang Z, Jin Q. Rapid identification of small interfering RNA that can effectively inhibit the replication of multiple influenza B virus strains. Antivir Ther. 2006, 11(4):431-8.

11. Zhang HY, Du Q, Wahlestedt C, Liang Z. RNA Interference with chemically modified siRNA. Curr Top Med Chem. 2006, 6(9): 893-900. 

12. Xiao RP, Zhu WZ, Zheng M, Cao CM, Zhang YY, Lakatta EG, Han QD. Subtype-specific alpha1- and beta-adrenoceptor signaling in the heart. Trends Pharmacol Sci. 2006, 27(6): 330-7.

13. Zaslavsky A, Singh LS, Tan H, Ding H, Liang Z, Xu Y.Homo- and hetero-dimerization of LPA/S1P receptors, OGR1 and GPR4. Biochim Biophys Acta. 2006, 1761(10):1200-12.


1. Ouyang K, Wu C, Cheng H. Ca2+-induced Ca2+ release in sensory neurons: low gain amplification confers intrinsic stability. J Biol Chem. 2005, 280(16):15898-902

2. Ouyang K, Zheng H, Qin X, Zhang C, Yang D, Wang X, Wu C, Zhou Z, Cheng H. Ca2+ sparks and secretion in dorsal root ganglion neurons. Proc Natl Acad Sci U S A. 2005, 102(34): 12259-64.

3. Wang X, Weisleder N, Collet C, Zhou J, Chu Y, Hirata Y, Zhao X, Pan Z, Brotto M, Cheng H, Ma J. Uncontrolled calcium sparks act as a dystrophic signal for mammalian skeletal muscle. Nat Cell Biol. 2005, 7(5):525-30.

4. Zhu WZ, Chakir K, Zhang S, Yang D, Lavoie C, Bouvier M, Hébert TE, Lakatta EG, Cheng H, Xiao RP. Heterodimerization of beta1- and beta2-adrenergic receptor subtypes optimizes beta-adrenergic modulation of cardiac contractility. Circ Res. 2005, 97(3):244-51.

5. Zheng M, Zhu W, Han Q, Xiao RP. Emerging concepts and therapeutic implications of beta-adrenergic receptor subtype signaling. Pharmacol Ther. 2005, 108(3):257-68.

6. Zheng M, Reynolds C, Jo SH, Wersto R, Han Q, Xiao RP. Intracellular acidosis-activated p38 MAPK signaling and its essential role in cardiomyocyte hypoxic injury. FASEB J. 2005, 19(1):109-11.

7. Zhu W, Zeng X, Zheng M, and Xiao R.P. The Enigma of beta2-adrenergic receptor Gi signaling in the Heart: the good, the bad, and the ugly. Circ Res. 2005, 97(6):507-9.

8. Chen XK, Wang LC, Zhou Y, Cai Q, Prakriya M, Duan KL, Sheng ZH, Lingle C, Zhou Z. Activation of GPCRs modulates quantal size in chromaffin cells through G and PKC. Nat Neurosci. 2005, 8(9):1160 - 8. 

9. Yang H, Zhang C, Zheng H, Xiong W, Zhou Z, Xu T, Ding JP. A simulation study on the Ca2+-independent but voltage-dependent exocytosis and endocytosis in dorsal root ganglion neurons. Eur Biophy J. 2005, 34(8):1007-16.

10. Wu B, Wang YM, Xiong W, Zheng LH, Fu CL, Bruce IC, Zhang C, Zhou Z. Optimization of a multi-channel puffer system for rapid delivery of solutions during patch-clamp experiments. Front Biosci. 2005,10:761-7.

11. Chen X, Wang L, Zhou Y, Zheng LH, Zhou Z. "Kiss-and-run" glutamate secretion in cultured and freshly isolated rat hippocampal astrocytes. J. Neurosci. 2005, 25(40): 9236-43.

12. Yao J, Chen X, Li H, Zhou Y, Yao L, Wu G, Chen X, Zhang N, Zhou Z, Xu T, Wu H, Ding J. BmP09, a “Long Chain” scorpion peptide blocker of BK channels. J Biol Chem. 2005, 280(15):14819-28.

13. Brochet DX, Yang D, Di Maio A, Lederer WJ, Franzini-Armstrong C, Cheng H. Ca2+ blinks: Rapid nanoscopic store calcium signaling. Proc Natl Acad Sci U S A. 2005, 102(8): 3099-104.


1. Xiao RP, Cheng H, Zhou Z, Chen Y, Wu C, Gu XC. Is China ready to go mainstream in molecular medicine? Nature. 2004, 432(7015): 42-5.

2. Xiao RP, Zhu W, Zheng M, Chakir K, Bond R, Lakatta EG, Cheng H. Subtype-specific beta-adrenoceptor signaling pathways in the heart and their potential clinical implications. Trends Pharmacol Sci. 2004, 25(7): 358-65.

3. Chen KH, Guo X, Ma D, Guo Y, Li Q, Yang D, Li P, Qiu X, Wen S, Xiao RP, Tang J. Dysregulation of HSG triggers vascular proliferative disorders. Nat Cell Biol. 2004, 6(9):872-83.

4. Wang SQ, Wei C, Zhao G, Brochet DX, Shen J, Song LS, Wang W, Yang D, Cheng H. Imaging microdomain Ca2+ in muscle cells. Circ Res. 2004, 94(8): 1011-22.

5. Wang W, Zhu W, Wang S, Yang D, Crow MT, Xiao RP, Cheng H. Sustained beta1-adrenergic stimulation modulates cardiac contractility by Ca2+/calmodulin kinase signaling pathway. Circ Res. 2004, 95(8):798-806.

6. Pepe S, van den Brink OW, Lakatta EG, Xiao RP. Cross-talk of opioid peptide receptor and beta-adrenergic receptor signalling in the heart. Cardiovasc Res. 2004, 63(3):14-22.

7. Leblais V, Jo SH, Chakir K, Maltsev V, Zheng M, Crow MT, Wang W, Lakatta EG, Xiao RP. Phosphatidylinositol 3-kinase offsets cAMP-mediated positive inotropic effect via inhibiting Ca2+ influx in cardiomyocytes. Circ Res. 2004, 95(12):1183-90.