Mitochondria play essential and pervasive roles in biology. The proper function of mitochondria is actively challenged by intrinsic stimuli, or by extrinsic pathogens and xenobiotics. Mitochondrial dysfunction has been implicated in aging and numerous diseases such as neurodegeneration, cardiovascular and metabolic diseases. However, it remains unclear as what constitute the mitochondrial quality control pathways that sense mitochondrial dysfunction, activate repair program and mitochondrial biogenesis, and eliminate damaged mitochondrial.
Our lab utilizes the model organism C. elegans, combining with the studies in mammals, to identify factors involved in mitochondrial quality control. The molecular mechanisms of these pathways will be further dissected with a combination of genetic, cellular and biochemical approaches. Understanding the mitochondrial quality control will hold great promise for the therapeutics of mitochondrial disorders and age-related diseases.
Current research projects: 1) molecular mechanism and regulatory factors of mitochondrial surveillance; 2) age-dependent loss of mitochondrial surveillance; 3) cell non-autonomous activation of the mitochondrial surveillance pathway; 4) starvation and energy sensing.
PI: Ying Liu, Ph.D.
Technician: Yanyan Yang, M.S. E-mail: cuishle.cn(AT)gmail.com
Graduate students: Chengchuan Ma, Liwa Shao
Guest students：Kaiyu Gao, Yi Li
Undergraduate students：Wei Liu
Address: Rm. 231, Integrated Science Research Center, Peking University