The mitochondrion is an eukaryotic organelle with its own genome. It plays versatile and pivotal roles in bioenergetics, calcium and redox homeostasis, cell survival and cell death. Not surprisingly, mitochondrial dysfunction is associated with more than 100 diseases including cardiometabolic diseases, cancer and neurodegenerative diseases. In 2008, we discovered that mitochondria undergo “superoxide flash”, i.e., sudden bursting production of superoxide anions in the matrix of a single mitochondrion. Triggered by transient openings of the mitochondrial permeability transition pore (mPTP), superoxide flashes constitute elemental ROS signaling events and are intimately linked to mitochondrial respiration, ATP synthesis and Ca2+ and homeostatic ROS regulation. Using the flash as a frequency-coded digital readout of mitochondrial function in intact cells and even in live animals, we aim at unraveling novel physiological and pathophysiological mechanisms underlying mitochondrial functional regulation and providing unique perspectives on the common etiology of so-called complex diseases.
Lab members:
Heping (Peace) Cheng, Ph.D.
Co-PI: Xianhua Wang, Ph.D.
Postdoctoral fellow: Peng Yu, Ph.D.
Technician: Yanru Wang, B.S. 
Secretary: Shuxin Du, B.S.
Graduate students: Liang Han, Xiaohu Huang, Wei Shang, Zhanglong Huang, Meng Ouyang, Tingting Hou, Di Wu, Jiejia Xu, Chongshu Jian, Fujian Lu, Yuan Lin
Guest students: Peng Yu, Cuiwei Sun
Undergraduate students:Xuefei Yuan, Xiao Huang, Tao Sun, Wenfeng Qi, Rongkang Yin

Address: Room 312 & 314, Ying-Jie Conference Center, Peking University
Phone: 86-10-6275-8383