Xiao-Wei Chen, Ph.D.

Principal Investigator

Laboratory of Molecular Metabolic Control

Room 220, Pacific Building, 52 Haidian Road

Peking University, Beijing, China 100871

E-mail: xiaowei_chen@pku.edu.cn

 

Dr. Xiao-Wei Chen received his B.S. in Biochemistry and Molecular Biology and B.A. in Economics from Peking University in 2002. He then obtained his Ph.D. in Physiology from the University of Michigan in 2008. He conducted his postdoctoral training at the Howard Hughes Medical Institute and the Life Sciences Institute at the University of Michigan, where he was subsequently appointed as a research investigator in 2013. In September 2014, he joined IMM as a full-time investigator.

 

Selected Publications:

1. Liu L, Cai J, Wang H, Liang X, Zhou Q, Ding C, Zhu Y, Xiao L, Fu T, Xu Z, Liu J, Yin Y, Fang L, Xue B, Wang Y, Meng ZX, He A, Li JL, Liu Y, Chen XW*, Gan Z*. Coupling of COPII vesicle trafficking to nutrient availability by the IRE1a-XBP1s axis. Proc. Natl. Acad. USA 2019 Jun 11;116(24):11776-11785.

2. Su L, Zhou L, Chen FJ, Wang H, Qian H, Sheng Y, Zhu Y, Yu H, Gong X, Cai L, Yang X, Xu L, Zhao TJ, Li Z, Chen XW*, Li P*. CIDEB controls sterol-regulated ER export of SREBP/SCAP by promoting cargo loading at ER exit sites. EMBO J. 2019 Apr 15; 38(8)

3. Nie C, Wang H, Wang R, Ginsburg D*, Chen XW*. A Dimeric Sorting Code Mediates Concentrative Cargo Enrichment by the COPII Complex. Proc. Natl. Acad. USA 2018 Apr 3;115(14):E3155-E3162.

4. Chen XW, Li S, Lin JD. The Micro-Managing Fat: Exosome as a New Messenger. Trends Endocrinol. Metab. 2017 May 10; S1043-2760(17)30063-2.

5. Nie C, Chen XW. Recycling of the insulin-responsive glucose transporter Glut4 regulated by the small GTPase RalA and the exocyst complex. Methods Cell Biol. 2015; 130:307-18.

6. Chen XW, Wang H, Pahuja KB, Zhang P, Meng ZX, Ma D, Bai Y, Liu H, Adams E, Baines A, Yu G, Sartor MA, Zhang B, Yi Z, Young SG, Schekman R, and Ginsburg D. SEC24A Deficiency Lowers Plasma Cholesterol through Reduced PCSK9 Secretion. eLife 2013 Apr 9;2:e00444. (Editor’s choice; also commented by DeBose-Boyd and Horton; highlighted by Faculty of 1000)

7. Chen XW, Saltiel AR. Ral’s Engagement with the Exocyst: Breaking UP is Hard to Do. Cell Cycle 2011 Jul;10(14):2299-304.

8. Chen XW, Leto D, Xiao J, Goss J, Wang Q, Shavit JA, Xiong TT, Yu GG, Toomre D, Ginsburg D, Xu Z, and Saltiel AR. Exocyst Function is Regulated by Effector Phosphorylation. Nature Cell Biol. 2011 May; 13(5):580-8. (Highlighted by Faculty of 1000)

9. Chen XW, Leto D, Xiong TT, Yu GG, Decker SJ, and Saltiel AR. A Ral GAP Complex Links PI 3-Kinase/Akt Signaling to RalA Activation in Insulin Action. Mol. Biol. Cell 2011 Jan; 22 (1):141-52. (Editorial Highlighted Paper)

10. Chen XW, Leto D, Chiang SH, Wang Q, Saltiel AR. The Activation of RalA is Required for Insulin-Stimulated Glut4 Trafficking to the Plasma Membrane via the Exocyst and the Motor Protein Myo1c. Dev. Cell 2007 Sep; 13(3):391-404.

11. Chen XW, Saltiel AR. TIRFing out Studies on Glut4 Trafficking. Dev. Cell 2007 Jan; 12(1):4-5.

12. Chen XW, Inoue M, Hsu SC, Saliel AR. RalA-Exocyst Dependent Recycling Endosome Trafficking is Required for the Completion of Cytokinesis. J Biol. Chem. 2006 Dec 15; 281(50): 38609-16.

13. Martin TD, Chen XW, Saltiel AR, Walker CL, Reiner DJ, Der CJ. Ral and Rheb GTPase Activating Proteins Integrate mTOR and GTPase Signaling in Ageing, Autophagy, and Tumor Cell Invasion. Molecular Cell (Cover story)

14. Xiao J, Chen XW, Davies BA, Saltiel AR, Katzmann D, and Xu Z. Structural Basis of Ist1 Function and Ist1-Did2 Interaction in MVB Pathway and Cytokinesis. Mol. Biol. Cell 2009 Aug; 20(15):3514-24.

15. Wang Q, Chen XW, Margolis B. Pals1 Regulates E-cadherin Trafficking in Mammalian Epithelial Cells. Mol. Biol. Cell 2007 Mar; 18(3):874-85.