Xiaojun Zhu

Associate Investigator

Co-Principal Investigator, Laboratory of Cardiovascular Development

Room 238, New Life Sciences Building, Peking University

Beijing, China 100871

E-mail: zhuxiaojun@pku.edu.cn

Phone: 86-10-6275-5291

 

Professional Experience:

1992-2000: Institute of Cardiovascular Research, Beijing Medical University

2000-2003: Research Associate in Cardiovascular Research Institute, Morehouse School of Medicine Atlanta, GA USA

2003-2005: Associate Professor in Health Science Center, Peking University

2005- : Associate Investigator in IMM, Peking University

Current research work is focused on the functional analyses of small G protein Rad in cardiovascular development, function and regeneration using zebrafish and mice.

Selected Publications:

1. Zhang J, Chang L, Chen C, Zhang M, Luo Y, Hamblin M, Villacorta L, Xiong JW,Chen YE, Zhang J, Zhu X. Rad GTPase inhibits cardiac fibrosis through connective tissue growth factor. Cardiovasc Res. 2011;91(1):90-8.

2. Sun Z, Zhang J, Zhang J, Chen C, Du Q, Chang L, Cao C, Zheng M, Garcia-Barrio MT, Chen YE, Xiao RP, Mao J, Zhu X. Rad GTPase induces cardiomyocyte apoptosis through the activation of p38 mitogen-activated protein kinase. Biochem Biophys Res Commun. 2011;409(1):52-7.

3. Luo Y, Zhang M, Zhang J, Zhang J, Chen C, Chen YE, Xiong JW, Zhu X. Platelet-Derived Growth Factor Induces Rad Expression through Egr-1 in Vascular Smooth Muscle Cells. PLoS One. 2011;6(4):e19408. 4. Wang G, Zhu X, Xie W, Han P, Li K, Sun Z, Wang Y, Chen C, Song R, Cao C, Zhang J, Wu C, Liu J, Cheng H. Rad as a novel regulator of excitation-contraction coupling and beta-adrenergic signaling in heart. Circ Res. 2010;106(2):317-27.（co-first author）

5. Zhu X, Lin Y, Bacanamwo M, Chang L, Chai R, Massud I, Zhang J, Garcia-Barrio MT, Thompson WE, Chen YE. Interleukin-1 beta-induced Id2 gene expression is mediated by Egr-1 in vascular smooth muscle cells. Cardiovasc Res. 2007 Oct 1;76(1):141-8. （corresponding author）

6. Chang L, Zhang J, Tseng YH, Xie CQ, Ilany J, Brüning JC, Sun Z, Zhu X, Cui T, Youker KA, Yang Q, Day SM, Kahn CR, Chen YE. Rad GTPase deficiency leads to cardiac hypertrophy. Circulation. 2007;116(25):2976-83.

7. Fu M, Zhang J, Tseng YH, Cui T, Zhu X, Xiao Y, Mou Y, De Leon H, Chang MM, Hamamori Y, Kahn CR, Chen YE. Rad GTPase attenuates vascular lesion formation by inhibition of vascular smooth muscle cell migration. Circulation. 2005;111(8):1071-7.

8. Wang Q, Zhu X, Xu Q, Ding X, Chen YE, Song Q. Effect of C-reactive protein on gene expression in vascular endothelial cells. Am J Physiol Heart Circ Physiol. 2005;288(4):H1539-45. （co-first author）

9. Lin Y, Zhu X, McLntee FL, Xiao H, Zhang J, Fu M, Chen YE. Interferon regulatory factor-1 mediates PPARgamma-induced apoptosis in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 2004;24(2):257-63. （co-first author）

10. Fu M, Zhu X, Zhang J, Liang J, Lin Y, Zhao L, Ehrengruber MU, Chen YE. Egr-1 target genes in human endothelial cells identified by microarray analysis. Gene. 2003;315:33-41. （co-first author）

11. Chen YE, Fu M, Zhang J, Zhu X, Lin Y, Akinbami MA, Song Q. Peroxisome proliferator-activated receptors and the cardiovascular system. Vitam Horm.2003;66:157-88. Review.

12. Zhu X, Lin Y, Zhang J, Fu M, Mao Z, Chen YE. Thiazolidinediones, a class of anti-diabetic drugs, inhibit Id2 expression through a PPARgamma-independent pathway in human aortic smooth muscle cells. Cell Mol Life Sci. 2003;60(1):212-8.

13. Fu M, Zhang J, Lin Y, Zhu X, Zhao L, Ahmad M, Ehrengruber MU, Chen YE. Early stimulation and late inhibition of peroxisome proliferator-activated receptor gamma (PPAR gamma) gene expression by transforming growth factor beta in human aortic smooth muscle cells: role of early growth-response factor-1 (Egr-1), activator protein 1 (AP1) and Smads. Biochem J. 2003;370(Pt 3):1019-25.

14. Zhang J, Fu M, Myles D, Zhu X, Du J, Cao X, Chen YE. PDGF induces osteoprotegerin expression in vascular smooth muscle cells by multiple signal pathways. FEBS Lett. 2002;521(1-3):180-4.

15. Fu M, Zhang J, Lin Yg Y, Zhu X, Willson TM, Chen YE. Activation of peroxisome proliferator-activated receptor gamma inhibits osteoprotegerin gene expression in human aortic smooth muscle cells. Biochem Biophys Res Commun. 2002;294(3):597-601.

16. Fu M, Zhang J, Lin Y, Zhu X, Ehrengruber MU, Chen YE. Early growth response factor-1 is a critical transcriptional mediator of peroxisome proliferator-activated receptor-gamma 1 gene expression in human aortic smooth muscle cells. J Biol Chem. 2002;277(30):26808-14.

17. Zhang J, Fu M, Zhu X, Xiao Y, Mou Y, Zheng H, Akinbami MA, Wang Q, Chen YE. Peroxisome proliferator-activated receptor delta is up-regulated during vascular lesion formation and promotes post-confluent cell proliferation in vascular smooth muscle cells. J Biol Chem. 2002;277(13):11505-12.

18. Fu M, Zhu X, Wang Q, Zhang J, Song Q, Zheng H, Ogawa W, Du J, Chen YE.Platelet-derived growth factor promotes the expression of peroxisome proliferator-activated receptor gamma in vascular smooth muscle cells by a phosphatidylinositol 3-kinase/Akt signaling pathway. Circ Res. 2001;89(11):1058-64.

19. Fu M, Zhang J, Zhu X, Myles DE, Willson TM, Liu X, Chen YE. Peroxisome proliferator-activated receptor gamma inhibits transforming growth factor beta-induced connective tissue growth factor expression in human aortic smooth muscle cells by interfering with Smad3. J Biol Chem. 2001;276(49):45888-94.