Jingwei Xiong, Ph.D.

Professor

Principal Investigator,

Laboratory of Cardiovascular Development

Room 102, New Life Sciences Building, Peking University

Beijing, China 100871

E-mail: jingwei_xiong@ pku.edu.cn

Phone: 86-10-6276-6239

 

Dr. Xiong received his Ph.D. in Cell Biology from Institute of Zoology at Chinese Academy of Sciences, Beijing. He then obtained his postdoctoral trainings on mouse developmental genetics at Mount Sinai School of Medicine and on zebrafish developmental genetics at Harvard Medical School. He joined the faculty as an Instructor, then a tenure-track Assistant Professor and Head of Laboratory of Developmental Vascular Biology at Harvard Medical School from 2002 to 2009. Since 2008, he has been a Professor and Head of Laboratory of Cardiovascular Development and Regeneration at the Institute of Molecular Medicine. He was a recipient of the Research Scientist Development Award (K01) from the US National Institute of Health (2002), the Harvard University Milton Scholar (2008), and Bayer Investigator Scholar (2014). His lab is working on cardiovascular development and regeneration using zebrafish, mice, and rat models. His researches are funded by the Ministry of Science and Technology of China, National Natural Science Foundation of China, and AstraZeneca-Innovation Center China.

Selected Publications (* corresponding authors):

1. Wang C, Faloon PW, Tan Z, Lv Z, Zhang P, Ge Y, *Deng H, and *Xiong JW. (2007). Mouse Lycat controls the development of hematopoietic and endothelial lineages during in vitro ES cell differentiation. Blood, 110, 3601-3609. (Comment by Drs. Ozuyaman and Kelm, Blood, 110, 3489).

2. *Xiong JW, Yu Q, Zhang J, and Mably JD. (2008). An acyltransferase controls the generation of hematopoietic and endothelial lineages in zebrafish. Circulation Research, 102:1057-1064. (Comment by Dr. Sybill Patan, Circ. Res., 102:1005-1007).

3. Xiong JW. (2008). Molecular and developmental biology of the hemangioblast. Developmental Dynamics, 237(5):1218-1231.

4. Wang X, Yu Q, Wu Q, Bu Y, Chang NN, Yan S, Zhu X, and *Xiong JW. (2013). Genetic interaction between pku300 and fbn2b controls endocardial cell proliferation and valve development in zebrafish. Journal of Cell Science, 126:1381-91.

5. #Chang N, #Sun C, Gao L, Zhu D, Xu X, Zhu X, *Xiong JW, and *Xi J (2013). Genome Editing with RNA-guided Cas9 Nuclease in Zebrafish Embryos. Cell Research, 23:465-72.

6. *Xiong JW and Chang NN (2013). Recent Advances in heart regeneration. Birth Defects Research (Part C): 99:160–169. Special Reviews on “Regeneration in Development”, Issue 2, September 2013.

7. *Hu XL, Chang NN, Wang X, Liu JH, Zhou FY, Zhu X and *Xiong JW (2013). Heritable gene targeting with gRNA/Cas9 in rats. Cell Research 23: 1322-1325.

8. Bu Y, Su F, Wang X, Gao H, Lei L, Chang NN, Wu Q, Hu K, Zhu X, Chang ZJ, *Meng K and *Xiong JW (2014). Ptpn9 regulates primitive erythroid cell development through Stat3 dephosphorylation in zebrafish. Journal of Cell Science,127(Pt 12):2761-70.

9. #Han P, #Zhou XH, Chang N, Xiao CL, Yan S, Ren H, Yang XZ, Zhang ML, Wu Q, Tang Y, Diao JP, Zhu X, Zhang CM, Li CY, *Cheng H, and *Xiong JW (2014). Hydrogen Peroxide Primes Heart Regeneration with a Derepression Mechanism. Cell Research, 24: 1091-1107. (Highlighted as a “featured article” on the journal cover)

10. #Gao H, #Bu Y, Wang X, Chang N, Lei L, Wu Q, Liu D, Zhu X, *Hu K, and *Xiong JW. (2015). Mecp2 Regulates Neural Cell Differentiation by Suppressing the Id1-Her2/Hes5 Axis in Zebrafish. J Cell Sci, 2015 May 6. pii: jcs.167874. [Epub ahead of print]

11. Diao J, Wang H, Chang N, Zhou XH, Zhu X, Wang J, and Xiong JW*. (2015). PEG-PLA Nanoparticles Facilitate siRNA Knockdown in Adult Zebrafish Heart. (Under minor revision to Developmental Biology)

12. #Wu Q, #Zhang J, Koh W, Yu Q, Amsterdam A, Zhu X, Davis G, Arnaout MA, and *Xiong JW. (2015). Talin1 is required for cardiac sarcomere assembly and endothelial cell integrity in zebrafish. FASEB Journal, 29:4989-5005.

13. Cheng F, Miao L, Wu Q, Gong X, Xiong JW*, and Zhang J*. (2016). Vinculin b deficiency causes epicardial hyperplasia and coronary vessel disorganization in zebrafish. Development, 143(19):3522-3531. 2016 Aug 30. pii: dev.132936. [Epub ahead of print].

14. Lei L#, Yan SY#, Yang R, Chen JY, Li Y, Bu Y, Chang N, Zhou Q, Zhu X, Li CY*, and Xiong JW*. (2016). Spliceosomal Protein Eftud2 Mutation Leads to p53-dependent Apoptosis in Neuronal Progenitors in Zebrafish. Nucleic Acids Research Advance Access published November 28, 2016; doi: 10.1093/nar/gkw1043.

15. Xiao CL#, Gao L#, Hou Y, Xu C, Chang N, Wang F, Hu K, He A, Luo, Y, Wang J, Peng JR, Tang F, Zhu X*, and Xiong JW*. (2016). Chromatin Remodeling Factor Brg1 Regulates Myocardial Proliferation and Regeneration in Zebrafish. Nature Communications, 7, 13787 doi: 10.1038/ncomms13787; Advance Access published December 8, 2016.

16. Yang R, Zhang Y, Huang D, Luo X, Zhang LR, Zhu X, Zhang XL, Liu Z*, Han J*, and Xiong JW*. (2017). Miconazole Protects Blood Vessels from MMP9-Dependent Rupture and Hemorrhage. Disease Models & Mechanisms, 10(3):337-348.