Yangming Wang, Ph.D.

Professor

PrincipalInvestigator

Laboratory of Stem Cells and Noncoding RNAs 

Institute of Molecular Medicine,

Peking University, Beijing, China100871

E-mail: ymw129@pku.edu.cn

Phone: 86-10-62766945

 

Professor Wang received his B.S. degree in Biotechnology from Peking University in 2000. He then joined Dr. Scott K. Silverman's laboratory to study nucleic acid biochemistry at the University of Illinois at Urbana-Champaign, where he obtained his Ph.D. degree in Biochemistry in 2006. After that, he became a postdoctoral fellow studying microRNAs and embryonic stem cells in Dr. Robert H. Blelloch's laboratory at the Unviersity of California, San Francisco. He became a principle investigator at the Institute of Molecular Medicine in 2011.

 

Selected Publications:

ORIGINAL PAPERS

14. Y. Wang, S. Baskerville, A. Shenoy, J.E. Babiarz, L. Baehner and R. Blelloch, “Embryonic Stem Cell Specific microRNAs Regulate the G1/S Transition and Promote Rapid Proliferation”, Nature Genetics 2008, 40, 1478-1483. (Highlighted in Nature Reports Stem Cells; featured in News and Views in Nature Genetics, 2008, 40, 1391-1392; previewed in Cell Stem Cell, 2009, 4, 9-10)

13. J.E. Babizrz, J.G. Ruby, Y. Wang, D.P. Bartel, and R. Blelloch, “Endogenous shRNAs, siRNAs, and Other Microprocessor-independent, Dicer-dependent Small RNAs in Mouse ES cells”, Genes & Development 2008, 22, 2773-2785.

12. Y. Wang, R. Medvid, C. Melton, R. Jaenisch, and R. Blelloch, “DGCR8 is Essential for microRNA Biogenesis and Silencing of Embryonic Stem Cell Self-Renewal”, Nature Genetics 2007, 39, 380-385.

11. Y. Wang and S.K. Silverman, “Experimental Tests of Two Proofreading Mechanisms for 5′-Splice Site Selection”, ACS Chemical Biology 2006, 1, 316-324.

10. Y. Wang and S. K. Silverman, “Efficient RNA 5'-Adenylation By T4 DNA Ligase to Facilitate Practical Applications”, RNA 2006, 12, 1142-1146.

9. E. Zelin, Y. Wang and S.K. Silverman, “Adenosine is Inherently Favored as the Branch-Site RNA Nucleotide in a Structural Context that Resembles Natural RNA Splicing”, Biochemistry 2006, 45, 2767-2771.

8. Y. Wang and S. K. Silverman, “A General Two-Step Strategy To Synthesize Lariat RNAs”, RNA 2006, 12, 313-321.

7. Y. Wang and S. K. Silverman, “Efficient One-Step Synthesis of Biologically Related Lariat RNAs by a Deoxyribozyme”, Angewandte Chemie International Edition 2005, 44, 5863-5866. (Highlighted in Nature Chemical Biology, 2005, 1, 195)

6. E. D. Pratico, Y. Wang, and S. K. Silverman, “A Deoxyribozyme That Synthesizes 2',5'-Branched RNA With Any Branch-Site Nucleotide”, Nucleic Acids Research 2005, 33, 3503-3512.

5. Y. Wang and S. K. Silverman, “Directing the Outcome of Deoxyribozyme Selections to Favor Native 3'-5' RNA Ligation”, Biochemistry 2005, 44, 3017-3023.

4. Y. Wang and S. K. Silverman, “Characterization of Deoxyribozymes that Synthesize Branched RNA”, Biochemistry 2003, 42, 15252-15263.

3. Y. Wang and S. K. Silverman, “Deoxyribozymes that Synthesize Branched and Lariat RNA”, Journal of the American Chemical Society 2003, 125, 6880-6881.

2. A. Flynn-Charlebois, Y. Wang, T. K. Prior, I. Rashid, K. A. Hoadley, R. L. Coppins, A. C. Wolf, and S. K. Silverman, “Deoxyribozymes with 2'-5' RNA Ligase Activity”, Journal of the American Chemical Society 2003, 125, 2444-2454.

1. W. Zhen, Y. Wang, W. Ding, X. Chen, Y. Hu, and Z. Lin, “Cre/loxP-mediated Deletion of Transgene in Transgenic Tobacco”, Journal (natural sciences) of Peking Univeristy 2001, 37, 477-482.

INVITED REVIEW

Y. Wang and R. Blelloch, “Cell cycle regulation by microRNAs in embryonic stem cells”, Cancer Research 2009, 69, 4093-4096.